John H McDonough Selected Research

VX (EDIM)

1/2019	Comparative efficacy of valnoctamide and sec-butylpropylacetamide (SPD) in terminating nerve agent-induced seizures in pediatric rats.
12/2011	In vivo microdialysis and electroencephalographic activity in freely moving guinea pigs exposed to organophosphorus nerve agents sarin and VX: analysis of acetylcholine and glutamate.
1/2011	The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs.
1/2007	Anticonvulsants for nerve agent-induced seizures: The influence of the therapeutic dose of atropine.
4/2003	Control of nerve agent-induced seizures is critical for neuroprotection and survival.

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John H McDonough Research Topics

Disease

25	Seizures (Absence Seizure) 09/2022 - 04/2003
19	Status Epilepticus (Complex Partial Status Epilepticus) 01/2021 - 02/2004
5	Epilepsy (Aura) 01/2020 - 01/2012
4	Poisoning 01/2021 - 09/2009
3	Neural Tube Defects (Exencephaly) 08/2015 - 02/2014
3	Coma (Comas) 12/2011 - 01/2007
2	Body Weight (Weight, Body) 01/2020 - 05/2015
1	Neuroinflammatory Diseases 01/2021
1	Gliosis 01/2021
1	Wounds and Injuries (Trauma) 01/2020
1	Brain Injuries (Brain Injury) 05/2015
1	Mania (Manias) 02/2014
1	Alzheimer Disease (Alzheimer's Disease) 01/2014
1	Bipolar Disorder (Manic Depressive Psychosis) 09/2013
1	Neuralgia (Stump Neuralgia) 09/2013
1	Organophosphate Poisoning 01/2012
1	Tremor (Tremors) 11/2010
1	Rhinorrhea 12/2009

Drug/Important Bio-Agent (IBA)

24	Nerve AgentsIBA 09/2022 - 04/2003
17	Anticonvulsants (Antiepileptic Drugs)IBA 09/2022 - 04/2003
16	SomanIBA 09/2022 - 04/2003
11	BenzodiazepinesIBA 09/2022 - 04/2003
7	SarinIBA 01/2019 - 04/2003
6	OrganophosphatesIBA 01/2021 - 01/2012
6	Acetylcholine (Acetylcholine Chloride)FDA Link 05/2019 - 11/2010
5	AcetylcholinesteraseIBA 05/2019 - 11/2010
5	VX (EDIM)IBA 01/2019 - 04/2003
5	Midazolam (Versed)FDA LinkGeneric 01/2018 - 04/2003
5	Pilocarpine (Ocusert)FDA LinkGeneric 01/2017 - 09/2013
5	Diazepam (Valium)FDA LinkGeneric 07/2010 - 04/2003
4	Cholinergic Antagonists (Anticholinergics)IBA 09/2022 - 04/2003
4	Scopolamine (Hyoscine)FDA Link 09/2022 - 01/2007
4	Pharmaceutical PreparationsIBA 01/2021 - 04/2003
4	sec-butyl-propylacetamideIBA 01/2019 - 08/2013
4	valnoctamideIBA 01/2019 - 09/2013
3	OximesIBA 09/2018 - 09/2009
3	Pentylenetetrazole (Metrazol)IBA 12/2014 - 01/2012
3	cyclohexyl methylphosphonofluoridate (cyclosarin)IBA 01/2011 - 04/2003
3	Atropine FDA LinkGeneric 09/2009 - 04/2003
2	nasIBA 01/2020 - 01/2018
2	Neuroprotective AgentsIBA 01/2020 - 05/2019
2	fosphenytoin (Cerebyx)FDA LinkGeneric 01/2020 - 02/2004
2	Phenobarbital (Luminal)FDA Link 05/2019 - 01/2019
2	TeratogensIBA 12/2014 - 02/2014
2	dipropylacetamide (valpromide)IBA 02/2014 - 01/2012
2	Valproic Acid (Depakote)FDA LinkGeneric 02/2014 - 08/2013
2	tabunIBA 01/2007 - 04/2003
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 09/2022
1	AntidotesIBA 09/2022
1	Isoflurophate (DFP)FDA Link 01/2021
1	ezogabine (retigabine)IBA 01/2021
1	Levetiracetam (Keppra)FDA LinkGeneric 01/2020
1	Propofol (Diprivan)FDA LinkGeneric 01/2020
1	Memantine (Namenda)FDA Link 05/2019
1	Aminobutyrates (Aminobutyric Acid)IBA 01/2019
1	PesticidesIBA 09/2018
1	Dexmedetomidine FDA Link 01/2018
1	Cholinesterases (Cholinesterase)IBA 01/2018
1	Cholinergic Agents (Cholinergics)IBA 01/2017
1	NeurosteroidsIBA 01/2017
1	LithiumIBA 01/2017
1	Paraoxon (E600)IBA 08/2015
1	Glutamic Acid (Glutamate)FDA Link 05/2015
1	CarboxypeptidasesIBA 05/2015
1	EnzymesIBA 05/2015
1	AmidesIBA 02/2014
1	phenserineIBA 01/2014
1	Amyloid (Amyloid Fibrils)IBA 01/2014
1	Proteins (Proteins, Gene)FDA Link 01/2014
1	Excitatory Amino Acid AntagonistsIBA 06/2012
1	Excitatory Amino AcidsIBA 06/2012
1	BicucullineIBA 01/2012
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 12/2010
1	Dizocilpine Maleate (Dizocilpine)IBA 01/2010
1	N-Methylaspartate (NMDA)IBA 01/2010
1	Muscarinic AntagonistsIBA 01/2010
1	P-30 composite resin (P 30)IBA 02/2004
1	Biperiden (Akineton)FDA Link 04/2003
1	Trihexyphenidyl (Artane)FDA LinkGeneric 04/2003

Therapy/Procedure

4	Therapeutics 01/2020 - 12/2010
2	Treatment Delay 01/2021 - 01/2020